Search results for "Ventilation mécanique"
showing 3 items of 3 documents
Analysis and modulation of the inflammatory response through lung agression related to bacterial infection and mechanical ventilation
2015
Despite major advances since decades in the management of ventilated patients, ventilator-associated pneumonia (VAP) continues to complicate the course of approximately 28% of the patients receiving mechanical ventilation (MV). Among patients hospitalized in intensive care units, the risk of pneumonia is 3- to 10- fold increased in MV patients. However, MV is often the only way to care for critically ill patients with respiratory failure. It has now been clearly demonstrated that MV, in particular adverse ventilatory strategies could activate lung cells, thus leading to a proinflammatory response, even in the absence of pathogen. This is the biotrauma paradigm, which accounts, at least in p…
Mitochondrial dysfunction and host immune response during pneumococcal pneumonia : impact of mechanical ventilation?
2020
Lung damage induced by mechanical ventilation (MV) worsens the prognosis of pneumonia. Mitochondrial dysfunctions could account for such deleterious effects. Accordingly, data obtained from both in vitro and in vivo experimental studies, as well as in ventilated patients with acute respiratory distress syndrome, show that mitochondrial alarmins, especially mitochondrial DNA, are released in the alveolar compartment as a result of the cyclic stretch, and could thus represent one link between the mechanical insult and the sterile inflammation leading to VILI (ventilator-induced lung injury). In rabbits, we show herein that adverse and prolonged MV worsens the prognosis of pneumococcal pneumon…
Impact de la modulation de la réponse inflammatoire pulmonaire et systémique de l'hôte mediée par Toll-Like Receptor 2 dans un modèle animal de pneum…
2012
EA MERS Hors CT hors EJ; Master